General Information
NameDr. Gad Vatine
DepartmentPhysiology and Cell Biology
Emailvatineg@bgu.ac.il
Academic RankSenior lecturer


Education

 
  • Postdoctoral: The Regenerative Medicine Institute, Cedars-Sinai medical Center, Los Angeles, CA

  • Ph.D: Department of Neurobiology, The Faculty of life science, Tel Aviv University

   

Research Interests

 
  • Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
  • Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
  • Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g. brain endothelial cells, pericytes, astrocytes and neurons.
  • Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
  • Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
   

Research Abstract

 
  • Our research aims to understand the mechanisms that underlie neurological disorders and develop personalized therapeutic approaches for patients. We use patient-specific stem cells to recreate diseases in a dish. Our main interest is to study the role of the blood brain barrier (BBB) in neurological disorders.
   

keywords

  

Blood brain barrier, BBB, iPSCs, neurological disease, disease modeling, personalized medicine, patient-specific stem cells, disease-in-a-dish