General Information
NameProf. Yoram Etzion
DepartmentPhysiology and Cell Biology
Emailtzion@bgu.ac.il
Academic RankAssociate Professor


Research position

 Director of Cardiac Arrhythmia Research Laboratory,
Soroka Medical Center and the Faculty of Health Sciences,
Ben-Gurion University of the Negev Beer-Sheva, Israel.
   

Education

 
  • 1993 B.A. (with honors), Pre-clinical studies to an M.D. degree, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel. 1995 M.Med.Sc. (with honors),Dept. of Physiology, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel. Advisor: Prof. Yoram Grossman. 2000 M.D., The Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel. 2001 Ph.D., Dept. of Physiology, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel. Advisor: Prof. Yoram Grossman. Thesis title: "High pressure effects on Purkinje cell firing and excitatory synaptic transmission in the guinea-pig cerebellum."
   

Research Interests

 
  • The Etzion laboratory has broad interest in cardiac biology. We are currently working on three main clinically-oriented topics:
  • (a) Pacing and arrhythmia research: our group developed unique tools for long-term pacing and arrhythmia studies in conscious rodents. We utilize these novel methodologies to study molecular mechanisms involved in atrial fibrillation, the most common arrhythmia in humans, as well as the molecular effects of electromechanical dyssynchrony, a major factor in heart failure progression.
  • (b) Cardiac repair and regeneration: The laboratory is involved in studies in collaboration with leading researchers from the department of biotechnology engineering. Our group utilizes cutting-edge methodologies to induce ischemic-cardiomyopathy and assess cardiac function following newly developed treatment modalities.
  • (c) Human-genetics studies: The laboratory collaborates with leading BGU researchers in this field and is involved in projects on newly identified mutations leading to dilated cardiomyopathy and atrial arrhythmias. Our main focus in these projects is to utilize in-vivo and in-vitro models (including iPSC-derived cardiomyocytes) to understand the molecular mechanisms leading to the human phenotype.
   

Research Projects

 

 

   

Research Awards

 

2009                   Post doctoral research fellowship award. American Heart Association (AHA), Midwest affiliate. Project title: High-throughput screening: a new approach to identify modifiers of macrophage foam cell formation. Supervisor: Dr. Anthony J. Muslin.

2009                   The "Neufeld Prize" of the Israel Heart Society, for original research paper in the field of cardiology. Awarded for the paper: "New Insights into the Atrial Electrophysiology of Rodents Using a Novel Modality: the Miniature-Bipolar Hook Electrode". Am J Physiol Heart Circ Physiol. 2008

2008                   American physician fellowship for Medicine in Israel. Awarded for a basic research post-doctoral fellowship at the Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, MO, USA.

2007                   Traval Grant to attend the AHA Scientific Sessions 2007 in Orlando. Awarded by the American Heart Association’s Council on Basic Cardiovascular Sciences.

2007                   Dr. Gabi and Eng. Max Lichtenberg Career Development Chair in Medicine, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.

2006                   The "Neufeld Prize" for original research study in the field of cardiology.  53 annual meeting of the Israeli Cardiology Society (April 2006, Tel-Aviv). Awarded for the study: "Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling."

2004                   Physican-Scientist award, "Prof. Yaacov Matzner and Prof. Amiram Eldor" fellowship, Bat Sheva De Rothschild Foundation and the Israel Health Ministry.

 

2004                   “Menachem Ronen award” for remarkable resident of internal medicine. Soroka Medical Center and Faculty of Health Sciences, BGU

   

Selected Publications

 

   

 

Beharier, O, Dror S, Levy S, Kahn J, Mor M, Etzion S, Gitler D, Muslin AJ,  Katz A, Moran A and Etzion Y. ZnT-1 protects HL-1 cells from simulated Ischemia-Reperfusion through activation of Ras-ERK signaling. J. Molecular Med. 2012 Feb;90(2):127-38. Epub 2011 Dec 23.

 

Zigel Y, Mor M, Zvi E, Zviling V, Gil O, Katz A and Etzion Y. A surface ECG-based algorithm to determine the atrial refractoriness of rodents during electrophysiological study. Cardiovascular Engineering and Technology 1011. Volume 2, Number 4, 388-398, DOI: 10.1007/s13239-011-0055-5

 

Etzion S, Etzion Y, Debosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010,  Dec;49(6):931-40

 

 

       Mor M, Shalev A, Dror S, Pikovsky O, Beharier O, Moran A, Katz A, Etzion Y. INO-8875, a Highly-Selective A1 Adenosine Receptor Agonist: Evaluation of Chronotropic, Dromotropic and Hemodynamic Effects in Rats. J Pharmacol Exp Ther. 2010, In-press, suspended (*).

          * The paper was accepted scientifically, but is suspended from final publication until the full chemical structure of INO-8875 will be exposed by the developing company.

   

        Shiry Levy, Ofer Beharier, Yoram Etzion, Merav Mor, Liat Buzaglo, Lior Shaltiel, Levi A Gaber, Anthony J Muslin, Amos Katz, Daniel Gitler and Arie Moran. The molecular basis for ZnT-1 action as an endogenous inhibitor of L-type calcium channels. J Biol Chem. 2009 Nov 20;284(47):32434-43

    

       Dvir T, Kedem A, Ruvinov E, Levy O, Freeman I, Landa N, Holbova R, Feinberg MS, Dror S, Etzion Y, Leor J & Cohen S. Pre-vascularization of cardiac patch on the omentum improves its therapeutic outcome. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14990-5

  

     Etzion Y and Muslin AJ. The Application of Phenotypic High-Throughput Screening Techniques to Cardiovascular Research (review). Trends in Cardiovasc Med 2009 Aug;19(6):207-12.

 

        Etzion Y, Hackett A, Proctor MB, Ren J, Nolan B, Ellenberger T, and  Muslin AJ. An Unbiased Chemical Biology Screen Identifies Agents That Modulate Uptake of Oxidized LDL by Macrophages. Circ. Res. 2009, Jul 17;105(2):148-57

 

        Etzion Y,  Mor A, Grossman Y. Differential modulation of cerebellar climbing fiber and parallel fiber synaptic responses at high pressure. J Appl Physiol. 2009 Feb;106(2):729-36.

 

        Etzion Y, Mor M, Shalev A, Dror S, Etzion O, Dagan A, Beharier A, Moran A,  Katz A. New Insights into the Atrial Electrophysiology of Rodents Using a Novel Modality: the Miniature-Bipolar Hook Electrode. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1460-9.

 

        Etzion Y, Ganiel A, Beharier O, Shalev A, Volvich L, Novack V, Abrahamov D, Matsa M, Sahar G, Moran A and Katz A. Correlation between Atrial ZnT-1 expression and atrial fibrillation in humans - a Pilot Study. J Cardiovasc Electrophysiol. 2008 Feb;19(2):157-64.

 

        Beharier O, Etzion Y, Katz A, Friedman H, Tenbosh N, Zacharish S, Bereza S, Goshen U, and Moran A. Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling. Cell Calcium 2007 Jul;42(1):71-82.